Columbian Exchange, Spanish Exploration, and Conquest

AP US History· difficulty 4/5

The first major impact of Columbus's voyages was on

A
$California's coastal valleys and Spanish mission settlements$
B
$The Caribbean islands (Hispaniola, Cuba), where Native populations collapsed$
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C
$Mainland North America, particularly the Eastern Woodlands$
D
$The Pacific Northwest and the Columbia River trading regions$

Explanation

The Tainos of Hispaniola were nearly extinct within a few decades.

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