Researchers studying caffeine tolerance gave four groups of mice daily caffeine doses for three weeks and then measured running-wheel activity (revolutions per hour) during a final test dose. Group 1 (no prior caffeine): 412; Group 2 (low daily dose): 380; Group 3 (medium daily dose): 290; Group 4 (high daily dose): 195. The researchers argued that tolerance to caffeine increases with the size of the prior daily dose. The strongest data point for this claim is ______
Which choice most logically completes the text using the data above?
- Acheck_circle
the steady decline in activity from Group 1 (412) through Group 4 (195) as prior dose size increased.
- B
Group 2's small drop from Group 1, suggesting low doses do little.
- C
Group 4's especially low activity.
- D
Group 1's high activity, since untreated mice were most active.
Explanation
The claim is that tolerance scales with prior dose size. Only choice B captures the monotonic relationship across all four groups, which is the strongest evidence for a dose-response pattern. Single data points (A, C, D) don't establish the trend.