A cell line is engineered to express cyclin B continuously rather than degrading it at the metaphase-to-anaphase transition. The most direct effect is
- A
Cells arrest at the G1/S checkpoint
- B
Cells skip mitosis entirely and replicate DNA continuously
- Ccheck_circle
Cells arrest in mitosis because anaphase requires cyclin B destruction
- D
Cells exit the cell cycle and enter senescence
Explanation
The APC/C ubiquitinates cyclin B at metaphase; degradation inactivates Cdk1 and lets sister chromatids separate. If cyclin B can't be destroyed, anaphase doesn't initiate — mitotic arrest.