Regulation of Cell Cycle

AP Biology· difficulty 3/5

p53 is a tumor suppressor that

A
$Stimulates the cycle by activating cyclin-CDK complexes$
B
$Halts the cycle and triggers apoptosis when DNA is damaged$
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C
$Replicates DNA at origins during S phase$
D
$Synthesizes proteins needed for spindle assembly$

Explanation

p53 is the "guardian of the genome" — DNA damage activates p53, which can pause the cycle for repair or trigger apoptosis. Loss of p53 is found in over half of all cancers.

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