Regulation of Cell Cycle

AP Biology· difficulty 3/5

The Anaphase-Promoting Complex (APC/C) drives mitotic progression by:

A
$Targeting cyclin and securin for ubiquitin-mediated degradation$
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B
$Synthesizing new cyclin B$
C
$Replicating DNA$
D
$Phosphorylating CDK directly$

Explanation

APC/C is an E3 ubiquitin ligase that polyubiquitinates securin (releasing separase) and mitotic cyclin (inactivating CDK), driving anaphase and exit from mitosis.

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