Biotechnology

AP Biology· difficulty 1/5

The plasmid map shows an origin of replication (ori), an ampicillin-resistance gene (amp^R), a multiple cloning site (MCS), and an EcoRI site.

EcoRI amp^R ori MCS pUC-like

Why is the amp^R gene important when cloning a foreign gene into this plasmid?

  • A

    It is the origin of replication for the plasmid.

  • B

    It cuts the foreign gene to insert it.

  • C

    It encodes the foreign protein of interest.

  • D

    It serves as a selectable marker so only transformed bacteria grow on ampicillin plates.

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Explanation

Selectable markers like amp^R allow researchers to grow only cells that took up the plasmid by plating on antibiotic-containing media. The ori drives replication; the MCS provides cloning sites.

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