Biotechnology

AP Biology· difficulty 3/5

Quantitative PCR (qPCR) was performed on cDNA from three tissues to compare gene expression of GeneX. Cycle threshold (Ct) values are reported (lower Ct = more starting transcript).

Tissue Ct Liver 18 Muscle 28 Brain 22

Which tissue has the highest GeneX expression?

  • A

    Liver, because lower Ct means more starting transcript.

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  • B

    All three express GeneX equally.

  • C

    Muscle, because higher Ct means more transcript.

  • D

    Brain, because Ct is intermediate.

Explanation

qPCR Ct is the cycle at which fluorescence crosses threshold; samples with more starting template reach threshold sooner (lower Ct). Liver (Ct=18) has the most transcript.

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