Signal Transduction

AP Biology· difficulty 3/5

Mutant Ras locked in the GTP-bound (active) state is one of the most common drivers of human cancer.

Why is constitutively active Ras oncogenic?

A
$It blocks DNA replication$
B
$It continuously activates the MAPK cascade, driving proliferation$
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C
$It forms apoptotic bodies$
D
$It phosphorylates p53 directly$

Explanation

Persistent Ras-GTP keeps Raf-MEK-ERK firing, producing chronic mitogenic signals that override growth controls.

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