Signal Transduction

AP Biology· difficulty 2/5

Adenylyl cyclase converts ATP to the second messenger cAMP at the inner face of the plasma membrane.

ATP adenylyl cyclase cAMP activates Protein Kinase A Phosphorylates target proteins → cellular response phosphodiesterase cAMP → AMP

A drug that inhibits cAMP phosphodiesterase would most directly cause:

  • A

    Prolonged activation of protein kinase A

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  • B

    Loss of receptor binding

  • C

    Decreased cAMP levels

  • D

    Inhibition of adenylyl cyclase

Explanation

Phosphodiesterase degrades cAMP to AMP, ending the signal. Inhibiting it allows cAMP levels to remain elevated, prolonging PKA activity.

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