Regulation of Cell Cycle

AP Biology· difficulty 3/5

Different cyclins peak at different cell-cycle stages and pair with their CDK partners.

cell cycle phase G1 S G2 M cyclin D cyclin E cyclin B

Cyclin D-CDK4/6 primarily drives:

  • A

    Mitotic entry at G2/M

  • B

    Chromosome segregation

  • C

    Progression through G1 toward S phase

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  • D

    Apoptosis

Explanation

Cyclin D rises early in G1; binding CDK4/6 inactivates Rb (retinoblastoma) protein, releasing E2F transcription factors and promoting entry into S phase.

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