Regulation of Cell Cycle

AP Biology· difficulty 3/5

p53 is the most commonly mutated gene in human cancers.

Why is p53 called the "guardian of the genome"?

A
$It coordinates arrest, repair, and apoptosis in response to DNA damage$
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B
$It replicates DNA$
C
$It assembles the nuclear envelope$
D
$It builds the spindle$

Explanation

p53 senses DNA damage and decides whether to pause the cycle for repair (via p21) or trigger apoptosis if the damage is too severe—protecting genomic integrity.

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