Insulin binds an RTK on muscle and adipose cells to recruit GLUT4 transporters from intracellular vesicles to the plasma membrane.
A failure of GLUT4 trafficking to the membrane in target cells would most directly cause:
- A
Hyperthyroidism
- B
Excess sodium retention
- Ccheck_circle
Insulin resistance and elevated blood glucose
- D
Cessation of mitosis
Explanation
Without GLUT4 insertion, target cells cannot take up glucose efficiently, leaving glucose in the blood—a hallmark of type 2 diabetes / insulin resistance.