Regulation of Cell Cycle

AP Biology· difficulty 3/5

normal APC K-Ras p53 malignant

The figure illustrates that cancer typically requires:

  • A

    Inhibition of one cell-cycle phase only

  • B

    Loss of all chromosomes

  • C

    Multiple successive mutations in proto-oncogenes and tumor suppressors

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  • D

    A single mutation in any gene

Explanation

Most cancers result from accumulation of several mutations affecting growth-promoting (oncogene) and growth-restraining (tumor suppressor) genes.

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