Signal Transduction

AP Biology· difficulty 3/5

Activation of a receptor tyrosine kinase (RTK) requires:

A
$Cleavage of the cytoplasmic kinase domain$
B
$Ligand-induced dimerization and cross-phosphorylation of tyrosines$
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C
$Binding of GTP to the receptor$
D
$Internalization into the nucleus$

Explanation

RTKs are activated when ligand binding promotes dimerization, allowing the two receptor monomers to phosphorylate tyrosine residues on each other (autophosphorylation).

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