At the replication fork, why is the lagging strand synthesized in fragments (Okazaki fragments)?
- A
DNA polymerase only synthesizes 3'→5', and one template runs parallel to fork movement
- B
DNA polymerase requires constant primer renewal, and the lagging template lacks helicase access
- C
DNA polymerase pauses at each origin, and the lagging strand encounters more replication origins
- Dcheck_circle
DNA polymerase only synthesizes 5'→3', and one template runs antiparallel to fork movement
Explanation
DNA polymerase requires a 5'→3' direction. The template for the lagging strand goes the wrong way, so synthesis happens in short pieces away from the fork, later joined by ligase.