A meta-analysis pooled 47 randomized trials comparing selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) for adult major depression. Acute remission rates were similar across the two monotherapies. However, in the 12-month follow-up subset, patients who had received CBT showed significantly lower relapse rates than those whose SSRI had been discontinued.
Which conclusion is best supported by the meta-analysis?
- A
Combined treatment is the only evidence-based approach for major depression.
- B
CBT works only for mild depression and should not be used as monotherapy.
- C
SSRIs are clearly superior because they act on neurotransmitter systems directly.
- Dcheck_circle
CBT and SSRIs produce comparable acute outcomes, but CBT may confer greater protection against relapse after treatment ends.
Explanation
The data show equivalent acute response but a long-term advantage for CBT after treatment discontinuation, consistent with skill consolidation. The other options either contradict the equivalence finding, dismiss CBT despite the data, or extrapolate beyond what was tested.