Biotechnology

AP Biology· difficulty 3/5

Cell counts on each plate (approximate colonies):

<ul> <li>P1 LB only: lawn (uncountable)</li> <li>P2 LB+amp: 240 colonies, none fluoresce</li> <li>P3 LB+amp+ara: 235 colonies, all fluoresce</li> <li>P4 LB+ara: lawn, none fluoresce visibly</li> </ul>
P1: LB P2: LB+amp P4: LB+ara P3: LB+amp+ara amp kills non-trans GFP+ colonies

What is the calculated transformation efficiency (transformants per microgram DNA) if 0.5 microgram of plasmid was used?

  • A

    About 120 transformants/microgram

  • B

    Cannot be calculated without dilution data

  • C

    About 480 transformants/microgram

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  • D

    About 240 transformants/microgram

Explanation

Transformants per microgram = colonies on selective plate / micrograms DNA. Using P2: 240 / 0.5 = 480 transformants per microgram. (In real experiments dilution and plating volume corrections may also apply.)

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