Chromosomal Inheritance

AP Biology· difficulty 4/5

A woman whose father had hemophilia A (X-linked recessive) marries an unaffected man. What is the probability their first son is affected?

  • A

    00 (mother does not carry the allele)

  • B

    1/41/4 (recessive Mendelian)

  • C

    11 (X-linked traits skip a generation)

  • D

    1/21/2 (mother is obligate carrier; sons get X from her)

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Explanation

Father with hemophilia → his daughter inherits his X with the allele → she is an obligate heterozygous carrier. Each son gets one X from her: 1/2 chance of the affected allele.

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