Non-Mendelian Genetics

AP Biology· difficulty 2/5

Coat color in Labradors involves two genes. The B locus controls pigment (B black, b brown). The E locus controls deposition (E pigment deposited, ee no deposition resulting in yellow regardless of B).

Coat color in Labradors B_ E_ -> Black bb E_ -> Brown __ ee -> Yellow (E gene blocks pigment deposition) F2 ratio from BbEe x BbEe: 9 black : 3 brown : 4 yellow

The 9:3:4 ratio indicates which type of gene interaction?

  • A

    Codominance between B and E.

  • B

    Independent assortment producing a 9:3:3:1 ratio.

  • C

    Incomplete dominance at the E locus.

  • D

    Recessive epistasis: ee masks expression at the B locus.

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Explanation

Homozygous ee blocks pigment deposition regardless of B genotype, masking the B-locus phenotype. The combined yellow class (3 BbEe-yellow + 1 bbee-yellow = 4) yields the modified 9:3:4 ratio characteristic of recessive epistasis.

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