Regulation of Gene Expression

AP Biology· difficulty 2/5

Which combination most likely silences gene expression?

A
$Loss of methyl groups from histones$
B
$Open chromatin plus enhancer activation$
C
$DNA methylation at CpG islands plus histone deacetylation$
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D
$Histone acetylation plus DNA demethylation$

Explanation

Methylation of CpG islands and removal of acetyl groups from histones tighten chromatin (heterochromatin), reducing transcription factor access and silencing transcription.

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