Structure of Water and Hydrogen Bonding

AP Biology· difficulty 4/5

During exercise, lactic acid floods the blood, threatening to drop pH. Blood maintains pH near 7.4 due to the bicarbonate buffer system: H2CO3 / HCO3-. The reaction is: CO2 + H2O <=> H2CO3 <=> H+ + HCO3-.

Time pH 7.4 Blood pH stays near 7.4 despite metabolic acid input

When acid (H+) is added to blood, which species in the buffer system primarily neutralizes it?

  • A

    Water splits into H+ and OH- to neutralize

  • B

    CO2 oxidizes the H+

  • C

    H2CO3 splits to release more H+

  • D

    HCO3- combines with H+ to form H2CO3

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Explanation

HCO3- accepts the added proton to form H2CO3, which can then dissociate to CO2 and H2O exhaled by the lungs, restoring pH.

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