Regulation of Gene Expression

AP Biology· difficulty 3/5

Beta-galactosidase activity (lac operon) was measured in E. coli grown under combinations of glucose and lactose.

Glucose Lactose Activity + - low + + low - - low - + high

The pattern is consistent with which regulatory logic?

  • A

    Lac operon is induced by lactose only when glucose is absent.

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  • B

    Lactose alone is sufficient to induce regardless of glucose.

  • C

    The operon is constitutive.

  • D

    Glucose induces the operon when lactose is present.

Explanation

High activity only when glucose absent and lactose present reflects dual control: cAMP-CAP activation requires low glucose; allolactose inactivates the lac repressor.

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