Translation

AP Biology· difficulty 3/5

A ribosome with three tRNA-binding sites (E, P, A) is shown translating an mRNA in the 5' to 3' direction.

ribosome 5' mRNA 3' E P A tRNAs with amino acids

During elongation, where is the next amino-acid-charged tRNA delivered, and where does the peptide bond form?

  • A

    Charged tRNA enters the A site; peptide bonds form between adjacent ribosomal subunits.

  • B

    Charged tRNA enters the A site; peptide bond forms between the A-site amino acid and the polypeptide on the P-site tRNA.

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  • C

    Charged tRNA enters the E site; peptide bond forms in the P site.

  • D

    Charged tRNA enters the P site; peptide bond forms in the E site.

Explanation

The aminoacyl (A) site receives the incoming charged tRNA; peptidyl transferase activity (in the large subunit rRNA) catalyzes peptide-bond formation between the A-site amino acid and the polypeptide on the P-site tRNA.

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