Regulation of Cell Cycle

AP Biology· difficulty 3/5

The M-checkpoint (spindle assembly checkpoint) prevents anaphase until:

A
$All kinetochores are attached to spindle microtubules$
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B
$The cell membrane has pinched$
C
$DNA is fully replicated$
D
$Cyclin levels reach a minimum$

Explanation

Even one unattached kinetochore generates a "wait" signal that inhibits APC/C. Only when all kinetochores are bipolarly attached does APC/C activate and trigger anaphase.

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