Cell Cycle

AP Biology· difficulty 2/5

The figure shows separated sister chromatids being pulled to opposite poles.

What molecular event triggers anaphase?

A
$Cyclin synthesis peaks$
B
$Separase cleaves cohesin holding sister chromatids together$
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C
$DNA replication completes$
D
$The nuclear envelope reforms$

Explanation

APC/C activates separase, which cleaves cohesin proteins binding sister chromatids. Once cohesin is cut, the chromatids are pulled apart by spindle fibers.

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