Introduction to Signal Transduction

AP Biology· difficulty 3/5

A defining structural feature of GPCRs is:

A
$An ion channel pore$
B
$Direct DNA-binding zinc fingers$
C
$An intrinsic kinase domain on the cytoplasmic tail$
D
$Seven transmembrane alpha-helices that span the plasma membrane$
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Explanation

G-protein-coupled receptors have a characteristic seven-transmembrane (7TM) structure that allows binding of a wide variety of ligands and coupling to heterotrimeric G proteins.

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