Cellular Respiration

AP Biology· difficulty 4/5

Phosphofructokinase (PFK) catalyzes step 3 of glycolysis. Its activity vs [ATP] is shown.

What kind of regulation is illustrated, and what is its biological purpose?

A
$Activation by NADH at high ATP$
B
$Allosteric feedback inhibition - high ATP slows glycolysis when energy is plentiful$
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C
$Competitive inhibition by glucose$
D
$Substrate-level phosphorylation increase$

Explanation

ATP allosterically inhibits PFK, the rate-limiting glycolytic enzyme. This is classic feedback inhibition: a downstream product slows its own production.

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