AP Biology · Topic 1.5

Structure and Function of Biological Macromolecules Practice

Part of Chemistry of Life.(SYI-1.E)

Practice questions

20

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Sample questions

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  1. Sample 1difficulty 2/5

    The <strong>primary</strong> structure of a protein refers to

    • A

      Its alpha helices and beta sheets

    • B

      Its three-dimensional folded shape

    • C

      Its sequence of amino acids

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    • D

      Multi-subunit assemblies

    Why

    Primary = sequence; secondary = local folds (helices/sheets); tertiary = overall 3D shape; quaternary = multi-chain assembly.

  2. Sample 2difficulty 2/5

    Triglycerides serve as long-term energy storage primarily because

    • A

      Their nitrogen-rich tails store energy more densely than sugars

    • B

      Their highly oxidized C-O bonds release ATP faster than glycogen

    • C

      Their polar ester linkages dissolve readily in cytosolic water

    • D

      Their highly reduced C-H bonds release more ATP per gram than carbohydrates

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    Why

    Lipids are more reduced (more C-H bonds) than carbs/proteins, so full oxidation releases ~9 kcal/g vs ~4 kcal/g for carbohydrates.

  3. Sample 3difficulty 2/5

    A peptide bond forms between

    • A

      Two carboxyl groups of adjacent residues

    • B

      A sulfhydryl group and an amino group

    • C

      A hydroxyl group and a phosphate group

    • D

      An amino group and a carboxyl group

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    Why

    The amino (-NH₂) of one amino acid joins the carboxyl (-COOH) of another via dehydration synthesis.

  4. Sample 4difficulty 2/5

    A triglyceride consists of

    • A

      Glycerol + three fatty acids

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    • B

      Three nucleotides

    • C

      Three glucose molecules

    • D

      A glycerol + phosphate + two fatty acids

    Why

    Glycerol provides three -OH groups to which three fatty acids are esterified.

  5. Sample 5difficulty 2/5

    All steroids share what structural feature?

    • A

      A phosphate-sugar repeating backbone

    • B

      A long fatty-acid hydrocarbon tail

    • C

      A four-fused-ring carbon skeleton

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    • D

      A polypeptide chain of amino acids

    Why

    The four-ring (three 6-carbon, one 5-carbon) sterol skeleton, with different side groups giving cholesterol, testosterone, etc.